Topic: exposure therapy

Social anxiety disorder (SAD) presents a significant challenge in mental health, often stemming from traumatic social experiences and manifesting as profound fear and avoidance in social contexts. As one of the most prevalent neuropsychological disorders across adolescence and adulthood, its clinical importance is undeniable. However, the absence of a robust animal model has hindered comprehensive research efforts. In response, we developed a Social Fear Conditioning (SFC) mice model, mirroring the process of exposure therapy used in clinical settings.To elucidate age-dependent behavioral patt

Anxiety disorders are among the most common mental disorders, having inappropriate learned fear and resistance to extinction as cardinal features. Exposure therapy represents a promising therapeutic approach, the efficiency of which depends on inter-individual variation in fear extinction learning. Previously we reported that the formation of fear memories is associated with a general downregulation of the tropomyosin receptor kinase C (TrkC) activation in the brain fear network. Particularly, inactivation of TrkC and of the downstream Erk1/2 signaling in the hippocampus is associated with the