Topic: extinction training

Opioid misuse for pain management has become a major global health problem, causing what has been called the opioid epidemic. Recently, D3 receptor (D3R) antagonists have arisen as a potential treatment to enhance cognition in memory-related diseases. In this work, we first used a 3-day extinction training (ET) previously reported to be successful to extinguish opiates-seeking behaviours motivated by their withdrawal-related contextual memories, such as the morphine withdrawal-induced conditioned place aversion (CPA) in rats. Secondly, we evaluated the impact of D3R blockade in the extinction

Addiction is a highly debilitating condition consisting of compulsive self-administration and seek for the substance of abuse, and its most challenging feature is the high rate of relapse. Addiction and relapse share similarities with a brain process called neural plasticity which acts through the Brain-Derived Neurotrophic Factor and its receptor TrkB. Moreover, Somatostatin (SST) expressing interneurons are involved in neuronal plasticity and are important in modulating cocaine-seeking behaviour in mice.We are testing the role of TrkB in Somatostatin(SST)-expressing neurons in the formation