Topic: FAAH

Consumption of cannabinoid-containing products has increased for their beneficial effects on pregnancy for reducing symptoms such as nausea, vomiting or anxiety. However, FDA clearly strongly advises against the use of delta-9-tetrahydrocannabinol (THC) during pregnancy. Alongside, mostly of the studies have investigated the effects of prenatal THC (pTHC) exposure, in males only, but pTHC shows a sex bias. Here, we investigate the effects of pTHC exposure in the male and female young rats.Sprague and Dawley rats were subcutaneously treated with THC (2 mg/kg/day) or vehicle (VHC), from gestatio

An estimated one-third of American veterans of the 1991 Gulf War continue to experience multiple unexplained health problems known as Gulf War Illness (GWI). GWI is a chronic disorder that is characterized by persistent and heterogeneous symptoms including but not limited to anxiety, pain, fatigue, and cognitive impairment. In the current study, we hypothesized that exposure to toxic chemicals during the Gulf War (GW) may produce a long-lasting disruption in the endocannabinoid (ECB) system, one of the brain’s endogenous anti-inflammatory mechanisms, leading to dysregulated microglial activati