Building a functional atlas of synaptic/dendritic signaling to compare young, healthy-aging, and pathological-aging brains
Michelle DSouza, Tannishtha Das, Nisha Ann Viswan, G V Harsharani, Aditi Bhattacharya, Upinder Singh Bhalla · FENS Forum 2024
Neurological diseases are complex network-level processes where many aspects of subcellular function undergo depletion, stress, and sometimes catastrophic decline. Conventional single-molecule studies have had limited success in uncovering these highly interconnected events. Our study utilizes network-level modeling with data from mass spectrometry and targeted data from proximity ligation assay to study processes in various synapses of neurological disorders. We aim to measure synaptic signaling across multiple readouts, stimuli, and genetic/aging contexts and use this to build an atlas and m
ePoster · Neuroscience