Topic: fear generalization

Experiencing traumatic events can lead to the development of posttraumatic stress disorder (PTSD) in susceptible individuals. Pinpointing risk factors and mechanisms that lower individual vulnerability to PTSD presents a significant clinical challenge with considerable promise in prevention and threapy. Here we aimed to identify pretrauma cognitive and emotional traits and their neurobiological correlates that predict posttrauma fear generalization, a core symptom of PTSD. An unbiased exploration of neurobehavioral vulnerability traits determining trauma-related fear generalization suggests pr

Posttraumatic stress disorder (PTSD) manifests in some trauma-exposed individuals through excessive fear generalization to safe contexts and difficulties extinguishing fear. While previous studies have implicated functional changes in fear-regulatory nodes a comprehensive understanding of network-wide alterations remains elusive. We employed a rodent model of PTSD to investigate whole-brain activity patterns associated with fear generalization. Male rats underwent uncontrollable footshocks and 28 days later we measured their generalized fear response in an altered/safe context. Based on freezi