Fear memory retrieval

…impairs hippocampal plasticity and memory. However, it is not clear how acute circadian distur

…of neurons that were recruited during fear learning that was termed “memory amplification mechanism”. This mechanism is mediated CaMKII dependent twofold increase of the strength of all inhibitory and all excitatory synapses in the cell. The key function of the amplification mechanism is to promote an already-formed memory to a dominant memory.Aim:Using TRAP2 genetically modified mice, we investigated the long-term retention of traumatic memory through an ampl

The inability to extinguish learned fear is a hallmark of trauma and stress-related disorders. The inhibitory learning fear extinction is an effective way to treat these disorders, however, the neurobiology of fear extinction has not been clarified. The Neuropeptide S (NPS) has been shown to promote arousal and anxiolytic-like effects and facilitate fear extinction. In rodents, NPS receptors (NPSR) are prominently expressed in brain structures involved in learning and memory. In humans, a correlation between the NPS system and female patients suffering from panic disorders has been shown. Alth