Topic: feedback loops

The functional logic of brain circuits of Drosophila neuropils is largely determined by local/intrinsic neurons. The architecture of the antennal lobe (AL), for example, is numerically dominated by its local neurons (LNs) that interact with olfactory sensory neurons (OSNs) and projection neurons (PNs) within and across glomeruli. Detailed connectomic data, e.g., the Hemibrain dataset, reveal a massive number of nested feedback loops among these three classes of neurons. Dissecting the role of these feedback circuits is key to the understanding the computation taking place in AL and beyond. How