Maternal high-fat diet disrupts hippocampal excitation-inhibition balance impairing cognitive function selectively in adult female mouse offspring
Chiara Musillo, Marianna Samà, Barbara Collacchi, Kerstin Creutzberg, Marco Riva, Alessandra Berry, Francesca Cirulli · FENS Forum 2024
Maternal high-fat diet (mHFD) during pregnancy leads to increased inflammation and oxidative stress, representing an important risk factor for fetal neurodevelopment. We have previously shown, in a mouse model of mHFD, sex-dimorphic negative outcomes in the adolescent offspring, disrupting hippocampal Bdnf-Nrf-2 crosstalk specifically in females. In this study, we hypothesize that sex-differences are still present during adulthood, affecting cognition and neurotransmission. Furthermore, we tested a maternal dietary supplementation with the antioxidant N-acetyl-cysteine (NAC) as a preventive st
ePoster · Neuroscience