Topic: FG7142

This study investigated the effects of pharmacologically distinct conventional antidepressants (amitriptyline, moclobemide, sertraline) and modulation of affective biases in rats. We tested each antidepressant in three different affective bias protocols (new learning protocol and modulation of negative affective biases associated with past experiences) and a reward learning assay (RLA) control. The affective bias test (ABT) requires animals to learn two independent and equal reward-value associations following control or drug treatment Any affective bias generated is quantified during a subseq

In humans, loss aversion is sensitive to stress, and patients with neurological or psychiatric illnesses are particularly vulnerable to the detrimental effects of stress that lead to suboptimal life-altering choices. The basolateral amygdala (BLA) and nucleus accumbens (NAc) are stress sensitive brain areas that alter extracellular levels of norepinephrine (NE) and dopamine (DA), respectively. However, the dynamics of neurotransmitter release in these brain regions during stress has not been systematically explored. We used pharmacology and fiber photometric analysis to elucidate the impact of