Topic: finite element method

Spinal neuromodulation via epidural electrical stimulation is a promising therapy for motor function restoration of patients with spinal cord injury. By applying specific sequences of electrical stimulation to the spinal cord through the electrode array, the patient can achieve multiple movements. However, one of main difficulties of this therapy is that the mapping between stimulation parameters and body motions is complex and ambiguous. To achieve specific actions, it often requires a large number of experiments to tune stimulation parameters. Individual differences of functional in

Astrocytes, a crucial glial cell type in the brain, play a vital role in maintaining ion and energy homeostasis while actively participating in neuronal information processing and memory formation. Calcium is considered the main readout signal of astrocytes. Several studies have shown a significant heterogeneity in morphology within brain regions like the hippocampus. To enhance our understanding of the morphology and function of cells, computational models can aid experiments. Oschmann et al. proposed a computational model integrating two glutamate pathways triggering calcium elevations: acti