Topic: firing activity

The $k$-cap (or $k$-winners-take-all) process is a simple model of firing activity and inhibition in the brain. The process models the formation of neural assemblies, a longstanding proposal for the representation of abstract concepts in the brain. It is applied to a directed graph as follows: in each iteration, a subset of $k$ vertices of the graph are identified as winners; the next round winners are the vertices that have the highest total degree from the current winners, with ties broken randomly. Previous theoretical analyses of neural assemblies model the connectome as a directed Erd\"

It was previously reported that the nitric oxide synthase (NOS) inhibitor agmatine had anxiolytic and antidepressant-like effects in rodents (Aglawe et al Brain Res Bull 167:37, 2021). Since serotonergic (5-HT) neurons of the dorsal raphe nucleus (DRN), expressing NOS, had lower excitability than the non-NOS expressing ones (Gartside et al Eur J Neurosci 51:1881, 2020), the anxiolytic and antidepressant-like effects of agmatine might involve stimulation of 5-HT neurons of the DRN. The present study aimed to examine this hypothesis. Acute and chronic effects of agmatine were tested. In acute ex