Topic: Fkbp5

Stress-related psychiatric disorders have been associated with polymorphisms in the gene encoding FK506-binding protein 5(FKBP5), a co-chaperone of the glucocorticoid receptor(GR). Stress response is coordinated by the hypothalamic-pituitary-adrenal(HPA) axis, through secretion of glucocorticoids(GC). Additionally, the HPA is a site of convergence of the circadian clock and the stress response systems. Physiologically, GCs act as molecular effectors of circadian rhythm that synchronize transcriptional and metabolic activity in peripheral tissues. However, not much is understood about the analo

Post-traumatic stress disorder (PTSD) is a multifaceted psychological disorder characterized by deregulated fear and stress responses. Etiology and progression of PTSD involve multiple neurochemical factors that interact in complex ways and consequently alter range of neurotransmitters systems. One of the most important is CRH system, which involvement in fear and stress response is well established. CRH acts through two receptors, CRHR1 that plays role in stress responding and anxious arousal and CRHR2 that is responsible for dampening the stress response initiated by activation of CRHR1. In