Topic: Fluoro-Jade C

To understand the human brain and its neurodegenerative diseases, as well as to develop appropriate treatments, we need to investigate human tissue. Human organotypic culture provides an excellent opportunity to examine cellular and network-level activities, as well as molecular changes at long-term, as this technique enables the maintenance of the brain tissue for several weeks with a preserved tissue structure and cellular connections. However, due to the slice preparation and culture technique, considerable changes occur in the cultured tissue. In this study, we explored neuronal degenerati

Cerebral hypoperfusion (CH) is a contributing factor to impairments observed in individuals diagnosed with Alzheimer's disease, vascular dementia and the elderly population. CH-induced brain damage is closely associated with oxidative stress (OS), manifested through disturbed prooxidative/antioxidative balance (PAB) within cells. Elevated levels of xanthine oxidase (XOD) are identified as a potential causal factor of OS, ultimately culminating in cell death. We aimed to investigate the protective effects of the hormone progesterone (P4) against CH‐induced OS and neurodegenerative pathologies i