Topic: Focal seizures

For pre-surgical evaluation of patients with focal seizures, stereoelectroencephalographic (SEEG) signals are routinely recorded to identify the epileptogenic zone network (EZN). This network consists of distant brain regions involved in seizure initiation. However, the mechanisms underlying typical SEEG patterns that occur during the transition from interictal to ictal activity in distant brain nodes of the EZN remain elusive.We analyzed SEEG signals recorded from the EZN (involving three distant neocortical brain regions) in 10 patients during the transition from interictal to ictal activity

Despite many different medications, 30% of epileptic patients remain drug-resistant, in particular those with mesial-temporal lobe epilepsy (MTLE). MTLE is characterized by focal seizures arising in the temporal lobe, and is associated with hippocampal sclerosis in 80% of patients, as well as with several cognitive and emotional comorbidities. Resection of the epileptogenic zone, although effective, is very invasive, risky and generates side effects. To develop a non-invasive and effective treatment, we evaluated the therapeutic potential of synchrotron-generated X-ray microbeams, an innovativ

Mesial temporal lobe epilepsy (MTLE) is a prevalent form of drug-resistant epilepsy characterized by focal seizures originating from the hippocampus and surrounding structures. Neurostimulation provides an alternative to surgery-ineligible patients with intractable seizures. Hippocampal low-frequency stimulation (LFS) has shown antiepileptic effects in animal studies and small clinical cohorts, yet its long-term effects and mechanisms remain unclear. This study investigates LFS effects on different types of epileptiform activity, spatial learning and anxiety, and synaptic plasticity.We used th