Topic: food addiction

ePoster: 2 ePosters

Deconstruction of the role of CB1 receptor in CaMKII+ neurons in the context of obesity, metabolic syndrome, binge-eating, and food addiction

Inigo Ruiz de Azua, Elena Martin-Garcia, Laura Domingo-Rodriguez, Rafael Maldonado, Beat Lutz · FENS Forum 2024

AIMS: The activation of CB1 receptor (CB1R) is reported to favor energy accumulation and promote resiliency against stress. The aim of this study is to elucidate whether CB1R expression in CaMKII+ neurons is sufficient to restore its role in the regulation of energy metabolism and contingent behaviors.METHODS: To this end, we applied a genetic strategy to reconstitute CB1R expression at endogenous levels in CaMKII+ neurons (CaMKII-CB1-RS).RESULTS: The rescue of CB1R expression in these neurons promotes feeding behavior causing fasting-induced hyperphagia, increased motivation and impulsivity t

ePoster · Neuroscience

Prefrontal-hippocampal neural dynamics underlying impulsive-like behavior in food addiction

Laura Ribalta Vilella, Pablo Calvé, Rafael del Villar, Jaime de la Rocha, Elena Martín-García, Rafael Maldonado · FENS Forum 2024

Food addiction is characterized by impulsive decision-making, compulsive food intake, and a loss of behavioral control toward highly palatable foods. Impulsivity has been described as a predictive vulnerability marker for addiction disorders. The ventral hippocampus (vHPC) to prelimbic medial prefrontal cortex (PL mPFC) pathway has been associated with impulsive operant responses towards highly palatable foods and food-motivated behaviors. However, the electrophysiological dynamics between these brain areas underlying impulsivity are not well understood.In the food addiction animal model, mice

ePoster · Neuroscience