Topic: FOOOF

Power spectra of local field potentials contain an aperiodic component that is believed to reflect the excitation/inhibition balance. Several studies have indicated that the aperiodic exponent is sensitive to levodopa in Parkinson’s disease, but there is no clear evidence of its relationship to PD motor symptoms. This study aims to explore the correlation between the aperiodic exponent of subthalamic nucleus activity and rigidity and bradykinesia.Fourteen PD patients underwent bilateral STN DBS surgery with temporary leads externalization. LFPs were recorded in OFF and ON states several days a

This study contributes to the investigation of true oscillatory activity within neurophysiological data, amidst the backdrop of aperiodic neural activity. Donoghue et al. (2020) showed that in MEEG narrowband power peaks can be distorted due to interactions with the aperiodic component of the power spectrum, complicating interpretations of oscillatory peaks. We validated the separation of aperiodic and oscillatory components in EEG data from three conditions — eyes open, eyes closed, and waiting for visual tasks —using IRASA (Irregular-Resampling Auto-Spectral Analysis, Wen & Liu, 2016) an