Topic: foot-shock

Hippocampal dentate gyrus (DG) is essential for encoding highly similar inputs into distinct neural representations. This function is mainly attributed to the sparsely firing excitatory granule cells. It is not known how excitatory DG neurons modify their firing patterns in response to different conditions, to facilitate learning. We studied the activity of excitatory DG neurons during discrimination fear conditioning task (FC) using in vivo one-photon calcium imaging in adult, healthy C57/black mice. We compared learning in males (n = 6) and females (n = 6) and further, in voluntarily running

Introduction: Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed in the urocortin 1 (UCN1) positive neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) having modulatory impact on stress adaptation. As post-traumatic stress disorder (PTSD) is triggered by disturbed stress adaptation, we hypothesized the regulatory role of EWcp/UCN1/Trpa1 neurons in PTSD.Methods: Male TRPA1 wild-type (WT) and knockout (KO) mice were exposed to two different models of PTSD. In single prolonged stress (SPS) paradigm, time spent immobility was measured during