Topic: footshock

The subiculum > hypothalamic path has critical roles in expressing defensive responses in a wide range of threatening situations. This path is engaged during exposure to a natural predator or its context, social defeat, and contexts related to physically harmful events. Previous data have shown that the ventral and intermediate subiculum provide strong projections to a continuum formed by the anterior hypothalamic nucleus (AHN) and juxtadorsomedial part of the lateral hypothalamic area (LHAjd). By combining track tracing, chemogenetic, and calcium imaging experiments, we focused on differen

Aversive events in our environment shape our behaviours. Instrumental behaviours are punished when an action results in an aversive event. Yet there are instances where behaviours appear inappropriately sensitive to potential threats. The neural underpinnings of these inappropriate behaviours are poorly understood. In a conditioned punishment task, we trained rats to press two levers for pellets. Their responding suppressed on one lever when it also earned a conditioned stimulus (CS+) that was paired with a footshock, whilst responding continued on the other lever that earned a neutral conditi