Topic: forced swim stress

Acute stress, as a protective mechanism to respond to an aversive stimulus, can be often accompanied by suppressing pain perception via promoting consistent burst firing of dopamine neurons. Besides, sensitive and advanced research techniques led to the recognition of the mesohippocampal dopaminergic terminals, particularly in the two hippocampal regions, CA1 and dentate gyrus (DG). Previous studies have shown that dopamine receptors within these two hippocampal regions play a critical role in antinociceptive responses induced by forced swim stress (FSS) in the presence of inflammatory pain. S

Stress induces catecholaminergic system adaptations implicated in the etiology of stress-related disorders. Adrenergic receptors (ARs) in the ventral tegmental area (VTA) regulate phasic dopamine (DA) release in the mesolimbic system, associated with stress-related behavioral responses. Recently we demonstrated that intra-VTA ALPHA2-ARs (but not ALPHA1-ARs) modulation of such DA release is altered by acute stress (electric footshock). However, effects of different kind of stressors (e.g. psychosocial vs physical) on intra-VTA ALPHA2-AR signaling remains to be demonstrated.We studied the impact