Topic: forced swimming test

Maternal high-fat diet (HFD) during pregnancy and lactation induces depression-like phenotype and provokes myelin-related changes in rat offspring, which persist even to adulthood. Due to the plasticity of the developing brain, we decided to analyze whether depression-like phenotypes and myelin-related changes in the early lifetime induced by maternal HFD could be reversed by the omega-3 fatty acid-enriched diet (Ω3D). We investigated the effects of the Ω3D from the post-weaning period until adulthood (63rd day of life) in offspring on the depressive-like behavior (forced swimming test, locomo

Several data suggest that the RFamide peptides - especially the prolactin-releasing peptide (PrRP) – play a role in the regulation of stress responses, the disturbances of which can cause many diseases, including depression. PrRP was identified as an endogenous ligand of the GPR10 receptor, but can also bind to the NPFF2 receptor. Here we would like to reveal the association between depressive-like behaviour and changes in the PrRP regulation. Fifteen minutes forced swimming test (FST) was used to induce depression-like symptoms in male Wistar rats. On the next day during a 6 min test we ident