Topic: formoterol

ePoster: 2 ePosters

Engaging the delayed non-match to position task in rats as a test of inflammatory-induced cognitive impairment and model to assess pro-cognitive anti-inflammatory agents

Matthew McAuslan, Danka Kozareva, Fionn Dunphy-Doherty, Myles Corrigan, Jack Prenderville, Andrew Harkin · FENS Forum 2024

The delayed non-match to position task (DNMTP) is a translational instrumental learning paradigm commonly applied preclinically to assess higher executive functions including attention and working memory in rats. In this study, the effects of acute inflammatory challenges were assessed on cognitive performance in the DNMTP task.. Male and female Wistar rats were trained to criteria on the task. Initially, in validating the test, the effect of treatment with the muscarinic receptor antagonist scopolamine (0.02mg/kg, s.c.), known to disrupt performance in the task, was confirmed. Sex differences

ePoster · Neuroscience

Polymeric nanoparticles as drug delivery tools for brain degenerative disorders: In vitro assessment and drug release properties

Rebecca Maher, Almudena Moreno Borrallo, Eduardo Ruiz-Hernandez, Andrew Harkin · FENS Forum 2024

Therapies for neurodegenerative disease are limited in efficacy and tolerability, largely due to poor drug penetration across the BBB and off-target effects. Polymeric nanoparticles (NPs) are advantageous for brain drug delivery due to their safety profiles, drug-loading capacity, controlled-release properties and potential for drug repurposing. The aim of this work was to perform in vitro screening of NPs synthesised using the FDA-approved poly(lactic co-glycolic acid) (PLGA) polymer as drug delivery vehicles in primary rat neurons and glia as a prerequisite for further assessment in animal m

ePoster · Neuroscience