Fornix

…white matter, ventricles, hippocampus, fornix, basal ganglia and thalamus, with further exploration of the brainstem and cerebellum. Traditional blunt dissection reveals major pathways, while axial, sagittal and coronal MRI comparisons connect anatomy to imaging. Consolidation and self-assessment sessions help participants test their recognition of structures. Live online via Zoom

Deep Brain Stimulation (DBS) of the hippocampal formation is currently investigated as a therapeutic approach for the treatment of memory disorders and epilepsy. Although various neurostimulation protocols have been extensively studied semi-acutely in epileptic patients, their refinement requires more standardized preclinical testing in non-human primates (NHP). However, targeting deep brain structures such as the hippocampal formation in NHP still remains a challenging task. Here, we present a technological framework for submillimeter targeting of the hippocampal formation in macaque monkeys

Deep brain stimulation (DBS) of the fornix is currently being trialled in the treatment of memory impairment, including in Alzheimer’s disease. Commonly, DBS is delivered continuously at 130Hz, but the effect on memory performance of such stimulation has been mixed. Clinicians have suggested that delivering stimulation timed to ongoing neural activity may enhance the efficacy of DBS. Theta oscillations in the hippocampus, which have been hypothesised to support learning and memory, may provide a read out of memory relevant neural activity. Supporting this, optogenetic stimulation of the hippoc

…namely: the corpus callosum, the fornix and the corona radiata. Ovine samples from three different subjects have been imaged using scanning electron microscope combined with focused ion beam milling. Particular focus has been given to the axons. For each tract, a 3D reconstruction of relat