Frontotemporal lobar degeneration

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are fatal neurodegenerative disorders with significant clinical and molecular overlaps. Critical events in their pathogenesis involve cytoplasmic mislocalization and loss of nuclear functions of TAR DNA-binding protein 43 (TDP-43). Notably, unconventional metabolic conditions like type 2 diabetes mellitus and dyslipidemia paradoxically correlate with a better prognosis in ALS and FTLD, hinting at potential metabolic pathways in TDP-43-associated neurodegeneration. To better understand the interplay between TDP-43

…wasteosomes in the three primary frontotemporal lobar degeneration (FTLD) proteinopathies: FTLD with tau (FTLD-tau), FTLD with TAR DNA-binding protein 43 (FTLD-TDP) and FTLD with Fused in