ePoster · Neuroscience
Wasteosomes (corpora amylacea) in frontotemporal lobar degeneration can contain tau, TDP-43, or FUS, reflecting the underlying proteinopathy
Raquel Alsina, Marta Riba, Clara Romera, Jaume del Valle, Carme Pelegrí, Laura Molina-Porcel, Jordi Vilaplana · FENS Forum 2024
Wasteosomes (or corpora amylacea) appear in the human brain with advancing age and in some neurodegenerative diseases. They have been proposed to accumulate waste substances and to contribute to a brain-cleaning mechanism. In this context, wasteosomes may have the potential to entrap some of the proteins that misfold, aggregate and accumulate in neurodegenerative diseases. In this work, we aim to characterize wasteosomes in the three primary frontotemporal lobar degeneration (FTLD) proteinopathies: FTLD with tau (FTLD-tau), FTLD with TAR DNA-binding protein 43 (FTLD-TDP) and FTLD with Fused in