Functional connectome

…The functional connectome captures how brain areas communicate and graph theory analyses can characterise this at a network level. We modeled typical developmental trajectories of the functional connectome using graph theory to explore network-level development during childhood and adolescence. Using resting state functional MRI, we measured functional connectivity between 106 ROIs (Harvard-Oxford atlas), in a cross-sectional

Anxiety and mood disorders significantly impact individual well-being and societal health, highlighting the need for a thorough understanding of their risk factors. While early life stress is widely recognized as a risk factor for multiple psychiatric conditions, the neurobiological mechanisms driving these effects are yet to be fully understood.In this collaborative study, we investigated the long-lasting consequences of developmental stress on adult brain function, increasing susceptibility to the aforementioned disorders.To investigate the long-lasting consequences of developmental stress,

Resting-state functional magnetic resonance imaging (MRI) has yielded seemingly disparate insights into large-scale organization of the human brain. The brain’s large-scale organization can be divided into two broad categories: zero-lag representations of functional connectivity structure and time-lag representations of traveling wave or propagation structure. In this study, we sought to unify observed phenomena across these two categories in the form of three low-frequency spatiotemporal patterns composed of a mixture of standing and traveling wave dynamics. We showed that a range of empirica

…organized patterns that constitute the functional connectome, with consequences for cognition and behavior. In this talk, I will argue that another shift is underway, driven by new insights from synergistic interrogation of the functional connectome using different acquisition methods. The human functional c

…its brain in order to directly measure functional connectivity at brain scale and cellular resolution. Specifically, we measure the sign, strength, direction, and temporal properties of the connections between neurons. We present a preliminary functional connectome, currently

…Differences in functional brain organisation have been observed in these conditions, but little is known about how they are related to a child’s profile of behavioural difficulties. We investigated whether behavioural difficulties are associated with how the brain is functionally organised in an intentionally heterogeneous and transdiagnostic sample of 957 children aged 5-15. We used consensus community detection to derive data-driven profiles of behavioural difficulties and constructed functional connectomes

Aggression is an ethologically complex behavior with equally complex underlying mechanisms. Here, I present data on one form of aggression, appetitive or rewarding aggression, and the behavioral, cellular and system-level mechanisms guiding this behavior. First, I will present one way in which appetitive aggression is modeled in mice, and extend aggression motivation to the concept of compulsive aggression seeking and relapse. I will then briefly highlight recent advances in computer vision and machine learning for automated scoring of aggressive behavior, the role of specific cell-types in