Functional imaging

…recently developed a set of molecular imaging tools that enable multiregional processing and plasticity in neural networks to be studied at a brain-wide scale in rodents and nonhuman primates. Here we will describe how a novel genetically encoded activity reporter enables information flow in virally labeled neural circuitry to be monitored by fMRI. Using the reporter to perform functional imaging of synaptically defined neural populations in the rat somatosensory sys

The ability to learn new spatial memories is thought to depend on the plasticity of neural circuits in the hippocampus, whose progressive degradation in Alzheimer’s disease (AD) leads to severe cognitive impairments. While decades of in vitro studies indicate that astrocytes regulate various forms of neuronal synaptic plasticity, how the interplay between hippocampal astrocytes and neurons underlies spatial memory in vivo remains unknown, as does its potential link to AD's pathogenesis.To address these challenges, we developed a spatial memory task where mice, tracked with DeepLabCut automated

The ability to encode visual motion information is an essential prerequisite for organisms to navigate their surroundings. For example, animals need to detect whole-field motion in order to stabilize themselves within their environment. While it is known that some features of naturalistic motion such as its directionality are already extracted in the retina, it is still unclear whether all the necessary cues are already available at these early stages. Here we take advantage of the optomotor response (OMR) behavior in the larval zebrafish to study how these animals respond to whole-field motio

…With ultra-high field functional imaging we investigated the functional architecture of the human entorhinal-hippocampal circuitry. We identified an organization that is consistent with convergence of information in anterior and lateral entorhinal subregions and the subiculum/CA1 border while keeping a second route specific for scene processing in a p

…from animal to human including functional imaging in patients, microneurography, industrial partnerships and trials of novel preventative approaches that are benefitting from the people, expertise and fac

…To accelerate the functional characterization of iPSC-derived neurons and the effect of compounds, reproducible and relevant results are necessary. In this webinar, the speakers will: Introduce high-resolution functional imaging of human iPSC