Topic: fUSI

Functional ultrasound imaging (fUSI) can record neuronal activity down to 20 mm depth in the brain, at finer resolution than functional magnetic resonance imaging. We developed an acquisition add-on, analysis and visualization pipeline that allows efficient identification of anatomical and functional layout of the brain in 3D. Leveraging the high signal quality of fUSI, we asked whether the acquisition of multi-cm 3D functional maps can be made compatible with chronic anesthetized experiment design. Since availability of large-brained species is low and their behavioral training can be prohibi

Long-term, stable access to brain function across scales enables the understanding of how brain organization evolves during development or aging. In large-brained animals, fMRI serves as a standard imaging option, albeit limited in its compatibility with other modalities that could probe activity at finer spatial and temporal scales. Functional ultrasound imaging (fUSI) offers ~150 µm spatial and up to 10 Hz temporal resolution. The cranial window required for fUSI allows other brain access modalities, e.g. Neuropixels probe or optogenetics. However, the development of multimodal brain access