Topic: G protein-coupled receptor 50

The ability to remember and recognize familiar conspecifics is essential for social interaction. Social memory disorders affect normal social interaction. Engram neurons relate to social memory formation with unclear mechanisms. G protein-coupled receptor 50 (GPR50) is an X chromosome-associated orphan receptor and is highly expressed in neurons. In this study, using social disorders mouse model establishing, chemical modulation, electrophysiology, and RNAseq, we herein report a novel role of GPR50 in social memory formation via activating engram neurons. Our results demonstrate that GPR50 upr

Mitochondrial dysfunction has been detected in the brains of patients with autism spectrum disorders (ASD) with unclear mechanisms. We herein identify that G protein-coupled receptor 50 (GPR50), which harbors two variations in male ASD patients at Δ502-505 and T532A, is required in mitophagy. GPR50, which does not distribute endogenously in the mitochondrion, is recruited to the damaged mitochondrion, where it marks the mitochondrial portion and recruits the assembling autophagosomes, eventually facilitating itself with the mitochondrial fragments to the autophagosomes. The above process is as