Topic: GABA-A receptor

Organoids derived from human stem cells present enormous potential to investigate aspects of human brain development. In this study, we hypothesised that brain organoids represent a suitable method for studying the shift in GABAergic transmission, from excitatory to inhibitory, during development. As several anaesthetics act via GABA receptors, we aimed to investigate how the anaesthetic propofol, known to be a GABA-A receptor agonist, may affect neuronal transmission in cerebral brain organoids at different developmental stages. Organoids cultivated from human embryonic stem cells (H1-ESC), w

In recent years, the interaction between glioma and brain cells has emerged as one important regulator of tumor progression. In order to investigate the molecular and physiologic alterations of the peritumoral neurons induced by glioma growth, we used two well-established glioma syngeneic cell lines: GL261 and CT-2A. We performed in vivo electrophysiological recordings of visual evoked potentials (VEPs) to longitudinally monitor the neural dysfunctions along with tumor progression. With respect to controls, glioma-bearing (GBM) mice showed a decay of visual responses that started from day 14 a