Topic: GABAAR

Autism spectrum disorder (ASD) is a term used to describe a wide variety of neurodevelopmental disorders that share manifestations and symptoms including intellectual disabilities, social impairments, delayed speech development and repetitive behaviors. Different animal models of ASD share similar electrophysiological and morphological aberrations at the neuronal level. In particular, previous studies have shown that the developmental maturation of GABAergic circuitry appears altered leading to an excitation/inhibition imbalance in the adult. During neurotransmission, the polarity of the GABAe

Treatment-resistant depression (TRD), which refers poor responses to adequate antidepressant treatment, have prominent cognitive impairment. Moreover, the depression patients with cognitive impairment could be a risk factor for dementia following aging. The lower aminobutyric acid type A receptor (GABAAR)-mediated activity and GABAB receptor (GABABR)-mediated activity was observed in prefrontal cortex (PFC) of patients with depression. Furthermore, the concentrations declined of both GABA in the PFC following the aging and at beginning of the mid-age has been found, suggesting the GABAergic sy