Topic: GABAergic circuitry

Autism spectrum disorder (ASD) is a term used to describe a wide variety of neurodevelopmental disorders that share manifestations and symptoms including intellectual disabilities, social impairments, delayed speech development and repetitive behaviors. Different animal models of ASD share similar electrophysiological and morphological aberrations at the neuronal level. In particular, previous studies have shown that the developmental maturation of GABAergic circuitry appears altered leading to an excitation/inhibition imbalance in the adult. During neurotransmission, the polarity of the GABAe

Mutations in the X-chromosome gene PCDH19 cause Developmental and Epileptic Encephalopathy-9 (DEE9), a rare neurodevelopmental disorder characterized by epilepsy, autism spectrum disorder and cognitive impairment. DEE9 is characterized by a peculiar gender preference, affecting mainly heterozygous females.Recently, it was found that in vivo mosaic expression of Pcdh19 impairs the maturation and migration of neurons and the GABAergic circuitry, leading to defects of excitation/inhibition (E/I) balance. Since the GABAergic parvalbumin interneurons (PVIs) are powerful regulators of pyramidal neu