Topic: GABAergic system

Treatment-resistant depression (TRD), which refers poor responses to adequate antidepressant treatment, have prominent cognitive impairment. Moreover, the depression patients with cognitive impairment could be a risk factor for dementia following aging. The lower aminobutyric acid type A receptor (GABAAR)-mediated activity and GABAB receptor (GABABR)-mediated activity was observed in prefrontal cortex (PFC) of patients with depression. Furthermore, the concentrations declined of both GABA in the PFC following the aging and at beginning of the mid-age has been found, suggesting the GABAergic sy

Alzheimer´s disease (AD) is one of the main neurodegenerative disorders of the 21st century, characterized by a progressive decline in cognitive function. One important mechanism in memory formation and learning is adult neurogenesis, the process by which new neurons arise from dentate neural stem cells (NSCs). Current research of our group suggests that NSCs are affected in their fate decisions by AD. We observed an increased proliferation of NSCs in the pre-plaque phase which is followed by a strong decline in the number of NSCs and adult neurogenesis. Factors modulating NSC proliferation du