Topic: gabra1

In recent years, the interaction between glioma and brain cells has emerged as one important regulator of tumor progression. In order to investigate the molecular and physiologic alterations of the peritumoral neurons induced by glioma growth, we used two well-established glioma syngeneic cell lines: GL261 and CT-2A. We performed in vivo electrophysiological recordings of visual evoked potentials (VEPs) to longitudinally monitor the neural dysfunctions along with tumor progression. With respect to controls, glioma-bearing (GBM) mice showed a decay of visual responses that started from day 14 a

Newly discovered group of natural antisense long non-coding RNAs, known as SINEUPs, exhibits the ability to ameliorate defective gene expression by enhancing mRNA translation. A subgroup of severe and drug resistant forms of epileptic encephalopathies (EEs) have been associated to the haploinsufficiency of the GABRA1 gene that, by coding for the α1 subunit of the main inhibitory synaptic receptor, leads to impaired GABAergic inhibition. By taking advantage of a heterozygous α1 knock-out mouse model of epilepsy (het-α1 KO), we exploit SINEUP approach to restore GABAergic inhibitory deficits. Co