Topic: Gad1

The brain undergoes important growth and plasticity during prenatal development. Altered activation of the glucocorticoid receptor (GR) system is one of the factors mediating stress effects during this time, likely through transcriptional dysregulation. To investigate these processes in a human-specific in vitro system, we used induced pluripotent stem cell-derived 3-dimensional brain organoids. To determine cell-type specific GR activation response, we profiled the transcriptomes of thousands of individual cells using single-cell transcriptomic analyses following glucocorticoids exposure acut

Progress in brain research is widely based on experimental approaches having the potential to advance the knowledge on fundamental biology. In particular, the increasing availability of data obtained by experimental techniques has boosted the development of data-driven mathematical models reproducing neuronal circuits. While cellular and subcellular resolution data have been extensively collected in animal models, experimental constraints have limited the acquisition of information about human neuronal cytoarchitectures and morphologies. In this context, high resolution data can be efficiently