Topic: GAD67-positive interneurons

Schizophrenia (SCZ) is a debilitating psychiatric disorder, affecting approximately 1% of the global population. Estimates of the heritability rate of SCZ range around 80%, suggesting a strong genetic component. Loss-of-function mutations in SETD1A have been linked to both SCZ risk and other neurodevelopmental phenotypes. SETD1A is involved in chromatin remodeling through its function as a H3K4 methyltransferase, but how SETD1A loss-of-function mutations lead to altered brain function remains unclear. In the present study, we aim to gain insight into functional consequences of reduced SETD1A f

The vast amount of gut microbiota demonstrates the ability to modulate brain function. Unlike the brain, the gut microbiota is highly accessible to direct interventions such as prebiotics, probiotics and antibiotics, and can be manipulated by lifestyle choices including diet. The dendrites of neurons are the main input compartment, and proper dendritic growth and arborization are critical for the proper functioning of the central nervous system. Most studies of dendritic growth have shown that the dendritic growth process is extremely dynamic. Although there is some evidence that the gut micro