Topic: gamma band

Synchronization of neural activity is a fundamental component of information processing in the nervous system. Precise axonal conduction is required for correlated spiking activity between pairs of neurons at the millisecond timescale. Previous studies report that myelin loss results in deficient action potential propagation and a loss of population synchronization in the gamma band. Loss of myelination in demyelinating diseases like multiple sclerosis (MS) results in impaired motor function in patients with MS. However, a deeper understanding of how demyelination alters the timing, synchrony

The prefrontal cortex (PFC) exhibits prominent oscillatory activity already during early development. In the mouse PFC, these oscillations develop a beta band [15-30 Hz] component during the second postnatal week. These fast oscillations increase in frequency and amplitude with age until stabilizing in the adult-characteristic gamma band [30-80 Hz] during the fourth postnatal week. Abnormal development of fast prefrontal oscillations has been reported for mouse models of schizophrenia and autism. Here, we investigate potential drivers of PFC peak frequency acceleration through simulations of r