Topic: GAP43

Maternal immune activation (MIA) has been implicated in offspring neurodevelopmental and psychiatric disorders, although it is unknown to what extent MIA affects neurodevelopment in the general population, and whether effects differ by sex. The current study was set within FinnBrain, a prospective birth cohort study based in Turku, Finland. We examined the association between maternal prenatal C-reactive protein (CRP), a commonly used systemic inflammatory marker, and white matter fractional anisotropy (FA) and mean diffusivity (MD) in infant and 5-year-old offspring, using voxel-wise statisti

Nuclear Dbf2-related protein (Ndr2) is a serine/threonine kinase in the subgroup of the AGC family kinases and a core member of the Hippo signaling. Ndr2 plays a key role in the differentiation and maturation of neurons, regulating dendritic and axonal growth through integrin receptors. Further work from our lab has demonstrated that the deletion of Ndr2 kinase can improve spatial memory in old mice (see presentation by Miguel del Angel). Moreover, analysis of the hippocampal proteome revealed a differential expression of GAP43 protein in aged Ndr2 KO mice compared to wild type (WT) mice. Whil

Spinal cord injury represents a complex and serious medical condition characterized by damage to the spinal cord, causing profound functional impairment. The consequences of such an injury may include paralysis, loss of sensation, and disruptions in vital bodily functions, such as bladder and bowel control. The renin-angiotensin system, predominantly acting through the AT1 receptor, regulates blood pressure and hydro-electrolytic balance. However, the AT2 receptor (AT2R) also plays a crucial role, especially in processes related to neuroregeneration. In the present study, the AT2R was stimulat