Topic: generalized seizures

Regression, understood as the loss of previously acquired behaviors, affects 20-30% of patients with Autism Spectrum Disorder (ASD). Nowadays, the mechanism behind this regressive process is still unknown. To improve our knowledge and find selected target treatments, it is important to establish a model with regressive features. Here, we showed that the Synapsin II Knockout (SynII KO) mouse loses previously acquired social and cognitive abilities in adulthood. Synapsin II is a presynaptic phosphoprotein belonging to the Synapsin family (Syns) involved in neuronal development and in the modulat

Mesial temporal lobe epilepsy (MTLE) is a prevalent form of drug-resistant epilepsy characterized by focal seizures originating from the hippocampus and surrounding structures. Neurostimulation provides an alternative to surgery-ineligible patients with intractable seizures. Hippocampal low-frequency stimulation (LFS) has shown antiepileptic effects in animal studies and small clinical cohorts, yet its long-term effects and mechanisms remain unclear. This study investigates LFS effects on different types of epileptiform activity, spatial learning and anxiety, and synaptic plasticity.We used th