A new family of multicolor genetically encoded indicators for fast, sensitive, and selective in vivo imaging of norepinephrine
Zacharoula Kagiampaki-Baimpaki, Valentin Rohner, Cedric Kiss, Sebastiano Curreli, Alexander Dieter, Maria Wilhelm, Masaya Harada, Sian N. Duss, Jan Dernic, Musadiq A. Bhat, Xuehan Zhou, Luca Ravotto, Tim Ziebarth, Laura Moreno Wasielewski, Latife Sönmez, Dietmar Benke, Bruno Weber, Johannes Bohacek, Andreas Reiner, J. Simon Wiegert, Tommaso Fellin, Tommaso Patriarchi · FENS Forum 2024
Norepinephrine (NE) is one of the main neuromodulators in the brain influencing a plethora of behavioral outputs including both autonomic and cognitive functions, such as emotional learning and stress responses, through a brain-wide network of projections emanating from the Locus Coeruleus (LC). Genetically encoded indicators engineered from G-protein-coupled receptors (GPCRs) have been proven essential tools for neuroscience enabling in vivo imaging of neuromodulators with high spatiotemporal resolution. Current state-of-the-art NE sensors allow for in vivo optical detection of NE, however, t
ePoster · Neuroscience