Dopamine-acetylcholine interplay and neural activity motifs in the striatum: Insights from a mouse delayed-go reaching task
Teris, Wing Kin Tam, Rasha Elghaba, Kouichi Nakamura, Julien Carponcy, Guy Yona, Peter J. Magill · FENS Forum 2024
The striatum intricately regulates motor and cognitive functions through the dynamic interplay of dopamine (DA), acetylcholine (ACh), and intrinsic neuronal firing, bearing profound implications for disorders like Parkinson's. However, the interaction between striatal DA and ACh, and their collective impact on striatal neuron activity in health and disease, are not fully understood. This study aims to elucidate the complex interplay between ACh, DA, and neuronal activity in the striatum during sensory and motor events. Utilizing a specialized Delayed-Go reaching task for head-fixed mice, we re
ePoster · Neuroscience