Topic: geniposide

Yueju, a Chinese traditional herbal medicine formula, has a rapid antidepressant action. We have previously identified two active ingredients from Yueju: two iridoids, geniposide (GM) and shanzhiside methyl ester (SM). Only co-treatment (GS) with GM (44 mg/kg) and SM (4.7 mg.kg) elicits synergistic rapid antidepressant action by activating polypeptide (PACAP) activity and its associated CaMKII–BDNF signalling the hippocampus. We further investigate whether chronic treatment with GM and SM are effective in eliciting antidepressant effects via enhancing hippocampal adult neurogenesis. Two mouse

Alzheimer’s disease (AD) is the most common neurodegenerative disorder, which is characterized by a progressive loss of neuronal cells in different brain’s regions, that lead to a functional cognitive impairment. Neurofibrillary tangle (NFT) is a primary biomarker of AD, which is formed by an abnormal accumulation of hyper phosphorylated Tau protein inside the neuronal cells. Effective treatment for neurodegenerative diseases (NDs) presents a clinical challenge. Natural products showed a promising role in treatment of neurodegenerative diseases (NDs). Geniposide is a natural extract from the f