Topic: Genome instability

Investigate the origins and consequences of genome instability in primary, immortalized and transformed cells in the Barlow laboratory. Projects examine DNA secondary structures, replication stress and damage in proliferating cells, genome integrity during replication and division, innate immune responses, neurodegeneration and adaptive immunity in mouse models. Genetics, molecular biology and next-generation sequencing are used to locate damage, understand consequences for division and metabolism, and identify disease mechanisms. The researcher will lead an independent project, develop assays