Genome organization

…Taekjip Ha’s biophysical analysis of genome organization and repair, Narry Kim’s work on post-transcriptional regulation, Michele Vendruscolo’s AI approaches to difficult drug targets, and Yasushi Okada’s imaging-based study of living cytoplasm. The programme includes a public lecture and reception on 23 November, scientific sessions on 24–27 November, and a Korean-participants-only society meeting on 28

The nucleus actively contributes to cellular function through its organization, mechanics and interactions with molecular and mechanical networks inside and outside the cell. This second EMBO | EMBL symposium examines the cell biology underlying nuclear function, complementing genomic studies of three-dimensional genome organization and transcription. Topics include the nuclear envelope, condensates, cell division, nuclear biophysics and mechanics, architecture, dynamics and subcompartments. The meeting brings together cell and molecular biologists, genomicists and physicists at different care

Exploration of genome organization and function in the HIV infected brain is critical to aid in the understanding and development of treatments for HIV-associated neurocognitive disorder (HAND). Here, we applied a multiomic approach, including single nuclei transcriptomics, cell-type specific Hi-C 3D genome mapping, and viral integration site sequencing (IS-seq) to frontal lobe tissue from HIV-infected individuals with encephalitis (HIVE) and without encephalitis (HIV+). We observed reorganization of open/repressive (A/B) compartment structures in HIVE microglia encompassing 6.4% of the genome

…for 3D folding and structural genome organization in the cell nucleus in all higher eukaryotes. Here, we discuss how megabase-scale chromatin domain and chromosomal compartment organization in adult mouse cerebral cortex is linked, in highly cell type-specific fashion, to multiple retrotransposon superfamilies which comprise the vast majority of mobile DNA elements in the murine genome. We show that neuronal megadomain architectures include an evolutionarily adaptive heterochromatic organization which, upon perturbation, unleashes p