Topic: genome-wide association study

Understanding the biological underpinnings of gene-environment interactions (GxE) in humans is challenging. Therefore, animal models, with their controlled genetic backgrounds and environments can provide invaluable insights. This study aims to identify the genetic background of a particular “freezing” behaviour observed in beagle dogs, as a mechanism coping with stress. An intriguing observation was made in 50 kennel-raised beagles: upon leaving the kennel, 14 exhibited "freezing" behaviour and remained immobile during the 30-minute test, while 9 showed normal activity and 27 dogs were initia

Immediate-early genes (IEGs) are a class of activity-regulated genes (ARGs) that are transiently and rapidly activated in the absence of de novo protein synthesis in response to neuronal activity. We explored the role of IEGs in genetic networks to pinpoint potential drug targets for Alzheimer’s disease (AD). Using a combination of network analysis and genome-wide association study (GWAS) summary statistics we show that (1) IEGs exert greater topological influence across different human and mouse gene networks compared to other ARGs, (2) ARGs are sparsely involved in diseases and significantly

Substance use disorders (SUD) and aggressive behaviour often co-occur within individuals, along with transdiagnostic behavioural traits such as risk-taking behaviour, impulsivity, irritability, neuroticism, or anxiety. This study investigates shared genetic risk factors across these phenotypes using public genome-wide association study (GWAS) data: five GWAS on SUD, two on aggressive behaviour, and seven on related behavioural traits. We calculated genetic correlations and identified trait-specific associated SNPs shared between these phenotypes using Polarmorphism. Also, we determined how the