Topic: gestational antibiotic administration

The prenatal microbiome influences offspring health, by potentially altering postpartum maternal behavior. Identified as microbiome disruptors, prenatal stress and gestational antibiotic administration pose risks to maternal and offspring health.We conducted two studies exploring the impact of 1.Antibiotic administration and 2.Stress during gestation on postpartum maternal behavior using Wistar rats. Additionally, we examined the potential benefits of a multi-strain probiotic intervention.In the first study, a subgroup of pregnant rats received an antibiotic cocktail (ampicillin+vancomycin+neo

The gestational gut microbiota exerts significant influence on infant neurobehavior and postnatal brain resilience. This study addresses challenges encountered in assessing the effects of gestational antibiotic administration (GAA) and perinatal asphyxia (PA) on offspring neurodevelopmental reflexes.A preliminary study evaluated the effects of an initial antimicrobial cocktail (GAA-1) and PA on Wistar rat offspring. GAA-1 was initiated on gestational day 11 using a cocktail comprising ampicillin, vancomycin, neomycin, clindamycin, and amphotericin-B, followed by PA exposure on postnatal day (P