Topic: ghrelin

Recently, a central role of butyrylcholinesterase (BChE) in pathogenesis of obesity has been proposed. As BChE was shown to inactivate a hunger hormone, ghrelin, it has been suggested to control appetite and glucose metabolism by regulating ghrelin signaling in hypothalamus. The aim of our study was therefore to investigate the relationship between obesity induced by high-fat/high-fructose diet and BChE activity. We studied impact of the diet-induced obesity on serum BChE and vise-versa an effect of BChE inhibition on obesity development. Adults male Wistar rats were fed with standard or high-

Obesity, a widespread health issue, accompanied by various metabolism-related disabilities, has emerged as a significant public health challenge. Primary intervention for obesity involves lifestyle changes, including dietary treatments. The ketogenic diet (KD) is increasingly recognized as a potential remedy for obesity, with its efficacy attributed to appetite suppression in the hypothalamus.The study aimed to evaluate how the metabolic changes in hypothalamus, associated with obesity affect the mechanisms responsible for appetite regulation during KD treatment.Adult male mice were subjected

Food odours are perceived before consumption and trigger physiological responses (e.g., appetite, saliva, digestive enzymes) to help the body prepare for ingestion. Importantly, smell perception through the olfactory bulb (OB) increases when hungry. The mechanism linking metabolism and olfaction remains unknown, but there is converging evidence that the olfactory system is a target for metabolic hormones associated with food intake regulation and may adapt the olfactory system to nutritional needs by promoting or inhibiting food-seeking. Here, we looked at the hormone ghrelin as a signal of en

Ghrelin modulates several biological functions via selective activation of the growth hormone secretagogue receptor (GHSR). GHSR agonists may be useful for the treatment of anorexia and cachexia while antagonists and inverse agonists may represent innovative options for the treatment of drug addiction. Thus, the identification and pharmacodynamic characterization of new GHSR ligands is of high interest. In the present work the label-free dynamic mass redistribution (DMR) assay has been used to evaluate the pharmacological activity of a panel of GHSR ligands, already reported in the scientific