Topic: gliogenesis

The main goal of the project is to define the neuro/gliogenesis during normal development of human cortex and to create immunophenotypic maps of human cortex morphogenesis.Cellular differentiation using key markers specific for neural and glial lineages, as well as antibodies to transcription factors and functional proteins of nervous system were studied on the material from the Collection of prenatal human development of AP. Avtsyn Research Institute of Human Morphology, Moscow. In 2021, the online project dedicated to the Collection had been granted by the FENS History Committee(https://brai

In the central nervous system (CNS), the formation of functional neuronal networks during development depends on the ability of neuroepithelial progenitor (NEPs) to generate neurons and glial cells – oligodendrocytes and astrocytes - in a highly specific manner, both temporally and spatially. In the ventral neural tube, depending on both its concentration and timing of exposure, Sonic Hedgehog (Shh) - released by the notochord and floor plate cells - regulates expression of transcription factors that demarcate distinct NEP domains dedicated to sequentially generate specific neuronal and glial

Down syndrome is a common neurodevelopmental condition and major genetic cause of intellectual disability. Although trisomy of chromosome 21 is long known as underlying cause, it is not well understood how the increased dosage of over 300 genes on chromosome 21 perturbs transcriptional and epigenetic programmes underlying neural differentiation, and effective therapies are lacking. Mouse models have suggested potential underlying mechanisms, but it is unclear to what extent these are recapitulated in the human brain.Here, we use single cell transcriptomics and epigenomics to generate an atlas