Topic: Glp1r

ePoster: 2 ePosters

Molecular connectomics reveals a glucagon-like peptide 1 sensitive neural circuit for satiety

Addison Webster, Jordan Becker, Chia Li, Dana Schwalbe, Damien Kerspern, Eva Karolczak, Elizabeth Godschall, Dylan Belmont-Rausch, Tune H. Pers, Andrew Lutas, Naomi Habib, Ali D. Guler, Michael J. Krashes, John N. Campbell · FENS Forum 2024

Liraglutide and other agonists of the glucagon-like peptide 1 receptor (GLP-1RAs) are effective weight loss drugs, but how they suppress appetite remains unclear. GLP-1RAs inhibit hunger-promoting Agouti-related peptide (AgRP) neurons of the arcuate hypothalamus (Arc) but only indirectly, implicating synaptic afferents to AgRP neurons. To investigate, we developed a new method combining monosynaptic rabies with single-cell transcriptomics to identify connected neurons in a genetically tractable manner: “RAMPANT” (Rabies Afferent Mapping by Poly-A Nuclear Transcriptomics). Applying RAMPANT to A

ePoster · Neuroscience

Western diet administration in aged mice results in sex-dependent cognitive and metabolic dysfunction: Preventive role of rosmarinic acid

Letizia Giona, Chiara Musillo, Michael Ristow, Kim Zarse, Karsten Siems, Sabrina Tait, Francesca Cirulli, Alessandra Berry · FENS Forum 2024

Unhealthy nutrition, such as that characterized by a westernized style, can lead to metabolic syndrome (MetS), a cluster of cardio-metabolic risk factors associated with increased incidence of cognitive dysfunction, reducing the quality of life during aging. By contrast, regular consumption of nutraceuticals may promote brain and metabolic health, with limited side effects. We investigated whether oral administration of the polyphenol rosmarinic acid (RA, 500mg/kg) might protect aged male and female C57BL/6N mice from cognitive decline and metabolic derangement upon western diet (WD, 5.28 kcal

ePoster · Neuroscience