Topic: glutamatergic cells

Cajal-Retzius (CR) cells are essential players in early brain development. In the first postnatal week (P0-P7), these glutamatergic cells densely populate the most superficial layer of the cerebral cortex, providing a transient source of excitatory inputs to immature pyramidal neurons. In the murine brain, CR cells are greatly reduced in the neocortex after postnatal week two, whereas in hippocampus, they persist throughout postnatal development and even into adulthood. During this time, they are integrated in the CA1 network, and recent work (Glærum et al. 2024) has showed that their persiste

While the interconnection of monoaminergic nuclei, namely the Raphe nucleus, Locus coeruleus (LC) and Ventral Tegmental Area (VTA) is widely acknowledged for its pivotal role in mediating diverse cerebral functions, the true complexity lies in the nuanced neuroanatomical and neurochemical diversity within each system. Recent discoveries have brought to light distinctive neuronal populations within the raphe nucleus or the LC, both projecting specifically to the VTA, main nucleus for dopamine secretion. The raphe nucleus is a neurochemically diverse hub, hosting not only serotonergic neurons bu