Topic: glutamatergic synaptic transmission

Neuromodulators like dopamine are critical regulators of associative learning. Indeed, dopaminergic neurons in the dorsal tegmental area interact with the lateral central amygdala (CEl) circuitry involved in fear behavior. Thus, fear learning modulates the microcircuit of the CEl composed of somatostatin-positive (SST+) and protein kinase C-positive (PKCδ+) neurons. During this process, dopamine 1 receptor (D1R) activation enables LTP induction in SST+ CEl neurons (Groessl et al. 2018, Nat Neurosci 21:952-962).In fact, a detailed analysis of dopaminergic cellular effects on synaptic transmissi

Temporal lobe epilepsy (TLE), the most common form of DRE, is associated with enhanced glutamate receptor-mediated hyperexcitability in the temporal lobe structures. The mechanism of regulation of aberrant glutamatergic activity in TLE is still elusive. Sema 3F regulates the AMPA receptor surface expression in post-synapse. In this study, we investigated the contribution of semaphorin3F (SEMA 3F) to glutamatergic synaptic activity in TLE rats' hippocampus and anterior temporal lobe (ATL). synaptic transmission in the hippocampus and ATL. Golgi-Cox staining was conducted to visualize alteration